Follistatin is a naturally occurring autocrine glycoprotein engineered for its potent inhibition of myostatin, activin A, and other signaling members of the TGF-β superfamily. Produced at >99% purity with a batch-specific COA. For laboratory and in vitro research use only. Not for human consumption. Not a medicine.
Follistatin is an autocrine glycoprotein encoded by the FST gene, acting as a high-affinity binding partner and potent antagonist to structural members of the transforming growth factor-beta (TGF-β) superfamily. By binding directly to ligands like myostatin and activin A, it prevents them from interacting with signaling receptors, rendering it a vital tool in skeletal muscle biology, metabolic pathway replication, and reproductive endocrinology assays.
Mechanistic & Cellular Target Channels
ActRIIB Receptor Blockade: Neutralizes myostatin and activin A vectors via competitive binding, blocking down-stream Smad2, Smad3, and Smad4 transcription loops that normally limit skeletal tissue growth.
Smad Pathway Suppression: Modulates localized cellular gene expression profiles to allow laboratory evaluation of accelerated tissue recovery and myofibre enlargement models.
Lipid & Mass Remodeling: Suppresses regulatory feedback networks to study variations in hepatic fatty acid accumulation, glucose sensitivity, and mass-to-adipose density transformations.
Primary Laboratory Research Applications
Skeletal muscle hypertrophy and cellular proliferation mapping.
Satellite cell differentiation and myogenic pathway preservation.
Adipose tissue biology and hepatic steatosis pathomechanics.
Polycystic ovary syndrome (PCOS) and reproductive axis signaling controls.
Follistatin vs Other Myostatin-Inhibition Tools
Feature
Follistatin (FS-315)
Follistatin (FS-288)
Myostatin Antibody
Primary Target
Myostatin + Activin A + BMPs
Myostatin + Activin A + BMPs
Myostatin only
Selectivity
Broad TGF-β antagonism
Broad TGF-β antagonism
Myostatin-selective
Cell Binding
No (Circulating form)
Yes (Tissue-bound form)
N/A
Activin Affinity
Low (~432 pM Kd)
High (~46.5 pM Kd)
None
Analytical Verification Specifications
Gene Profile:
FST (Chromosome 5q11.2)
Total Mass Content:
1mg (1,000 mcg)
Purity Benchmark:
≥99.0% (HPLC & Mass Spectrometry Verified)
Primary Isoforms:
FS-288 (Tissue) / FS-315 (Circulating)
Formulation Vector:
Lyophilized Vacuum Solid Cake
⚠️ Preclinical Integrity Notice
All laboratory assets documented within this registry are distributed exclusively for verified laboratory research, analytical control trials, and foundational in vitro testing models.These chemical compounds are strictly not approved for human therapeutic, clinical, veterinary, or diagnostic administration.
